Evidence-Based Medicine (EBM) is the explicit, conscientious, and judicious integration of current best evidence from systematic research with individual clinical expertise in making decisions about patients (D Sackett 1996).
Course Objectives
  • Appreciate the importance of striving for a clear understanding of available evidence underlying clinical decisions.
  • Understand critical limitations to the practice of EBM, including time constraints, absence of evidence, and lack of evidence supporting EBM.
  • Reinforce an understanding of foundational statistical principles that underpin EBM.
  • Enhance their skill appraising and applying evidence related to screening, diagnosis, prognosis, therapy, and harm.
  • Recognize that evidence is necessary but not sufficient for good care: exceptional decision-making requires placing evidence into the context of burden, cost, and patient values and preferences.


Foundations of EBM Reliability of p-values
Screening Tests
Diagnostic Tests
Prognosis and Harm
Pooling Data
Clinical Applicability
How Good Is Our Evidence?