Journal Club: Articles Reviewed: 2014

July 21, 2014

Article: Yealy DM, et al. A randomized trial of protocol-based care for early septic shock. NEJM. 2014 May; 370(18): 1683-1693.


Domain: Pulmonary/Critical Care; Hypothesis testing, p values, alpha and beta error, confidence intervals
Discussant: Matt Churpek, MD, MPH, PhD
Reviewers: Demetra Gibson, Jeff Jacobs, Katie Lee,


July 28, 2014

Article: Sogaard KK, et al. Risk of Venous Thomboembolism in Patients with Liver Disease: A Nationwide Population-Based Case Control Study. The American Journal of Gastroenterology. 2009 January; 104: 96-101.

Domain: GI/Hepatology; odds ratio
Discussant: Donald Jensen, MD
Reviewers: Melissa Arredondo, Nikhil Bassi, Justin Boike, Xiao Wan


August 4, 2014

Article: Appel LJ, et al. Intensive Blood-Pressre Control in Hypertensive Chronic Kidney Disease. NEJM. 2010; 363: 918-929.

Domain: Nephrology; relative risk
Discussant: Anna Zisman, MD
Reviewers: Jason Alexander, Kate Lurain, Baldeep Pabla, Allison West, Maureen Willcox


August 18, 2014

Article: Papazian L, et al. Neuromuscular Blockers in Early Acute Respiratory Distress Syndrome. NEJM. 2010; 363: 1107-1116.

Domain: Pulmonary/Critical Care; sample size and power calculations
Discussant: Jason Poston, MD
Reviewers: Bryan Eberle, Yasmin Karimi, Will Karkowsky, Will Parker, Matt Stier


August 25, 2014

Article:Davies C, et al. Long-term effects of continuing adjuvant tomoxifen to 10 years versus stopping at 5 years after diagnosis of estrogen receptor-positive breast cancer: ATLAS, a randomised trial. Lancet. 2013 Mar 9;381(9869):805-16

Domain: Oncology; RCTs Part I (terminology)
Discussant: Erica Stringer, MD
Reviewers: Lane Benes, Jeremy O’Connor


September 22, 2014

Article: Boden WE, et al. Optimal Medical Therapy with or without PCI for stable coronary artery disease. N Engl J Med. 2007 Apr 12;356(15):1503-16.

Domain: Cardiology; RCT Part II (biases)
Discussant: Atman Shah, MD
Reviewers: Pat Lyons, Karen Schultz, Anita Turk, Mike Huber, Mike Putman


September 29, 2014

Article: Prickett SR, et al. Ara h 2 peptides containing dominant CD4+ T-cell epitopes: Candidates for a peanut allergy therapeutic. J Allergy Clin Immunol. 2011 Mar;127(3):608-15.

Domain: Allergy and Immunology; translational research
Discussant: Raoul Wolf, MD
Reviewers: Malini Soundarrajan, Tom Lu, Alex Gyftopolous


October 6, 2014

Article: Buse JB, et al. Exenatide once weekly versus liraglutide once daily in patients with T2DM (DURATION-6): a randomised, open-label study. Lancet 2013; 381: 117–24.

Domain: Endocrinology; sensitivity, specificity, ROCs
Discussant: Celeste Thomas, MD
Reviewers: Raj Jain, Lindsay Esch, Cory Henderson, Anne Goodenow, Miz Mimoto


October 13, 2014

Article: Goldenberg JZ, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database of Systematic Reviews 2013, Issue 5.

Domain: Hospital Medicine; heterogeneity, I-squared values, and Forest plots for metanalyses
Discussant: Madhu Yarlagadda, MD
Reviewers: Michelle Martincheck, Andy Levy, Chris D’Angelo


October 20, 2014

Article: Fava C, et al. Effect of CPAP on BP in Pts with OSA/Hypopnea: A Systematic Review and Metanalysis. CHEST 2014; 145(4):762–771

Domain: Sleep Medicine; funnel plots for metanalyses
Discussant: Jay Balachandran, MD
Reviewers: Emily Escue, Karen Dugan, Jennifer Seo, Andrew Hantel


November 3, 2014

Article: McMurray, et al. Angiotensin-Neprilysin Inhibition versus Enalapril in Heart Failure. N Engl J Med 2014;371:993-1004.

Domain: Cardiology; survival curves and hazard ratios
Discussant: Francis Alenghat, MD
Reviewers: Joe Venturini, Nilu Khan, Aaron Wolfson


November 10, 2014

Article: Temel, et al. Early Palliative Care for Patients with Metastatic NSLC. N Engl J Med 2010;363:733-42..

Domain: Palliative Care; comparison of means (paired and unpaired t tests)
Discussant: Charles Rhee, MD
Reviewers: Kyle Karches, Mike Drazer, Laura Dickens, Mike Jelinek, Kershaw Patel


November 17, 2014

Article: Estruchl, et al. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90.

Domain: Cardiology/General Medicine; stats review
Discussant: Sachin Shah, MD
Reviewers: Gray Akoegbe, Eric Brandt, Cheryl Steiman, Joseph Wynne


November 24, 2014

Article: Polonsky, et al. Coronary Artery Calcium Score and Risk Classification for Coronary Heart Disease Prediction. JAMA 2010;303(16):1610-1616.

Domain: Cardiology/Kappa Statistic
Discussant: Tamar Polonsky, MD
Reviewers: Rita German, Nikhil Narang, Nate Steiger, Aaron Tannenbaum, Jin Yoo


December 1, 2014

Article: Sommers, et al. Changes in Mortality after Massachusetts Health Care Reform. Ann Intern Med. 2014;160:585-593.

Domain: Health Care Policy/Regression Analyses
Discussant: David Meltzer, MD
Reviewers: Ben Kenigsberg, Nikki Welch


December 8, 2014

Article: Rohatgi, et al. HDL cholesterol efflux capacity and incident cardiovascular events. NEJM. 2014; 371:2383-2393.

Domain: Cardiology
Discussant: James Liao, MD
Reviewers: Ellis Christian, Tien Dong, Matt Modes, Jacqueline Poston, Eleanor Valenzi


December 15, 2014

Article: Clarke, et al. Exercise and associated dietary extremes impact on gut microbial diversity. Gut. 2014;63:1913–1920.


Domain: Translational Research/GI/Microbiome
Discussant: Eugene Chang, MD
Reviewers: Anthony Sofia, Amy Reid, Steve Healan, Jon Erlich, Femi Kassim